ENDOTHELIN-BINDING INHIBITORS, BE-18257A AND BE-18257B .1. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

被引：30

作者：

KOJIRI, K

IHARA, M

NAKAJIMA, S

KAWAMURA, K

FUNAISHI, K

YANO, M

SUDA, H

机构：

[1] BANYU PHARMACEUT CO LTD,OKAZAKI RES LABS,OKAZAKI 444,JAPAN

[2] BANYU PHARMACEUT CO LTD,CENT RES LABS,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 12期

关键词：

D O I：

10.7164/antibiotics.44.1342

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized I-125 ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis. These binding inhibitors were extracted with methanol from mycelium and purified by HPLC.

引用

页码：1342 / 1347

页数：6

共 6 条

[1] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].