PROTECTIVE EFFECT OF FRUCTOSE-1,6-BISPHOSPHATE AGAINST CARRAGEENAN-INDUCED INFLAMMATION

被引：20

作者：

PLANAS, ME ^{[1
]}

SANCHEZ, S ^{[1
]}

GONZALEZ, P ^{[1
]}

DEOLIVEIRA, JR ^{[1
]}

BARTRONS, R ^{[1
]}

机构：

[1] DIANORM,E-08006 BARCELONA,SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 237卷 / 2-3期

关键词：

FRUCTOSE 1,6-BISPHOSPHATE; CARRAGEENAN; ANTIINFLAMMATORY; LIPOSOME;

D O I：

10.1016/0014-2999(93)90276-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Administration of carrageenan (0.5 mg) to the plantar tissue of rats resulted in reversible inflammatory injury. This damage was monitored as changes in foot volume, using a plethysmometer. Administration of fructose 1,6-bisphosphate at different doses, orally or intraperitoneally, prevented the inflammatory action induced by the simultaneous injection of carrageenan in the rat paw. The effect was dose and time dependent. In contrast, fructose or fructose 6-phosphate afforded no significant protection. In order to extend the average half-life of the drug, we prepared liposomes of fructose 1,6-bisphosphate which, administered orally or intraperitoneally, showed a greater and more prolonged antiinflammatory action. The significance of these findings with respect to the mechanism of the antiinflammatory action of fructose 1,6-bisphosphate is discussed.

引用

页码：251 / 255

页数：5

共 20 条

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