PRESENCE OF 2-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1,2-DIMETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, NOVEL ENDOGENOUS AMINES, IN PARKINSONIAN AND NORMAL HUMAN BRAINS

被引:87
作者
NIWA, T
TAKEDA, N
YOSHIZUMI, H
TATEMATSU, A
YOSHIDA, M
DOSTERT, P
NAOI, M
NAGATSU, T
机构
[1] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 464,JAPAN
[2] NAGOYA UNIV,BRANCH HOSP,DEPT INTERNAL MED,NAGOYA,AICHI 464,JAPAN
[3] MEIJO UNIV,FAC PHARM,NAGOYA,AICHI 468,JAPAN
[4] JICHI MED SCH,DEPT NEUROL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
[5] FARMITALIA CARLO ERBA SPA,RES & DEV,MILAN,ITALY
[6] NAGOYA INST TECHNOL,DEPT BIOSCI,NAGOYA,AICHI 466,JAPAN
关键词
D O I
10.1016/0006-291X(91)91831-V
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
2-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline were identified for the first time as novel endogenous amines in parkinsonian and normal human brains by gas chromatography-mass spectrometry. It is of interest that these tetrahydroisoquinolines are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which produces Parkinson's disease. © 1991.
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页码:603 / 609
页数:7
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