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NONSPECIFIC ACTIVITY OF (+/-)-CP-96,345 IN MODELS OF PAIN AND INFLAMMATION

被引：53
作者：
NAGAHISA, A
ASAI, R
KANAI, Y
MURASE, A
TSUCHIYANAKAGAKI, M
NAKAGAKI, T
SHIEH, TC
TANIGUCHI, K
机构：
[1] Department of Medicinal Biology, Central Research Division, Pfizer Inc., Taketoyo, Aichi, 470-23
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 107卷 / 02期
关键词：
CP-96,345; NONPEPTIDE NK1-RECEPTOR ANTAGONIST; PAIN; INFLAMMATION;
D O I：
10.1111/j.1476-5381.1992.tb12737.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The non-peptide NK1 receptor antagonist, CP-96,345, and its 2R,3R enantiomer CP-96,344, which is not an NK1 receptor antagonist (IC50 > 10 muM), were evaluated for antinociceptive and anti-inflammatory activities in several classical models of pain and inflammation in the rat. Both CP-96,345 and CP-96,344 reduced carrageenin-induced paw oedema and hyperalgesia, and attenuated the second phase of formalin-induced paw licking with equal potency. These results indicate that NK1 antagonism is not responsible for the activity of (+/-)-CP-96,345 in the above animal models.
引用
收藏
页码：273 / 275
页数：3
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