INOSITOL TREATMENT RAISES CSF INOSITOL LEVELS

被引：54

作者：

LEVINE, J

RAPAPORT, A

LEV, L

BERSUDSKY, Y

KOFMAN, O

BELMAKER, RH

SHAPIRO, J

AGAM, G

机构：

[1] ABARBANEL MENT HLTH CTR,BAT YAM,ISRAEL

[2] BEN GURION UNIV NEGEV,FAC HLTH SCI,MINIST HLTH MENT HLTH CTR,IL-84105 BEER SHEVA,ISRAEL

[3] BEN GURION UNIV NEGEV,FAC HLTH SCI,SOROKA MED CTR,BIOCHEM LAB,IL-84105 BEER SHEVA,ISRAEL

来源：

BRAIN RESEARCH | 1993年 / 627卷 / 01期

关键词：

INOSITOL; CEREBROSPINAL FLUID; BLOOD BRAIN BARRIER; 2ND MESSENGER;

D O I：

10.1016/0006-8993(93)90761-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-brain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.

引用

页码：168 / 170

页数：3

共 16 条

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AGAM G, UNPUB HIGH DOSE PERI

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