RAPID CLEARANCE OF HEPATITIS-C VIRUS-RNA IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF PATIENTS WITH CLOTTING DISORDERS AND CHRONIC HEPATITIS-C TREATED WITH ALPHA-2B INTERFERON IS NOT A PREDICTOR FOR SUSTAINED RESPONSE TO TREATMENT

被引:30
作者
PEERLINCK, K
WILLEMS, M
SHENG, L
NEVENS, F
FEVERY, J
YAP, SH
VERMYLEN, J
机构
[1] UNIV HOSP GASTHUISBERG, CTR MOLEC & VASC BIOL, LOUVAIN, BELGIUM
[2] UNIV HOSP GASTHUISBERG, DEPT INTERNAL MED, DIV LIVER & PANCREAT DIS, LOUVAIN, BELGIUM
关键词
HEPATITIS C; INTERFERON; HEMOPHILIA; PBMC;
D O I
10.1111/j.1365-2141.1994.tb04835.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thirteen patients with congenital coagulation disorders and chronic hepatitis C were treated with alpha-interferon (IFN). Serum transaminases (ALT) and hepatitis C virus (HCV)-RNA in plasma and peripheral blood mononuclear cells (PBMC) were followed during and after treatment. During IFN treatment ALT levels normalized in 8/13 patients. In all patients HCV-RNA disappeared from PBMC. In 9/13 HCV-RNA also became undetectable from plasma; in six of these nine this occurred earlier in PBMC than in plasma; in the remaining three the disappearance of HCV-RNA occurred simultaneously in plasma and PBMC. All but two patients relapsed within 3 weeks after cessation of IFN, one relapsed after 6 weeks and one patient remains in remission after 6 months. HCV-RNA reappeared either earlier in plasma (3/12) or simultaneously in plasma and PBMC (9/12). Viral replication in PBMC thus can easily be suppressed by IFN, whereas longer treatment is needed for the eradication of HCV-RNA in plasma. The detection of HCV-RNA in PBMC cannot be used as a prognostic marker for the identification of patients with chronic hepatitis C who will have a sustained response to IFN treatment.
引用
收藏
页码:816 / 819
页数:4
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