FORMATION OF C-C BOND IN SOLID-PHASE SYNTHESIS USING THE HECK REACTION

被引：78

作者：

HIROSHIGE, M ^{[1
]}

HAUSKE, JR ^{[1
]}

ZHOU, P ^{[1
]}

机构：

[1] ARRIS PHARMACEUT CORP,S SAN FRANCISCO,CA 94080

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 26期

关键词：

D O I：

10.1016/0040-4039(95)00855-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium promoted vinylation of aryl iodide bound to a solid support was studied. Under the reaction conditions of water/DMF/Pd(OAc)(2)/PPh(3)/base, the reaction proceeds smoothly and leads to moderate to high yield of product at 37 degrees C after 4-18 hours.

引用

页码：4567 / 4570

页数：4

共 9 条

[1] DRUG DISCOVERY ON THE ASSEMBLY-LINE
ALPER, J
[J]. SCIENCE, 1994, 264 (5164) : 1399 - 1401
[2] GALLOP MA, 1994, J MED CHEM, V37, P1232
[3] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS
GORDON, EM
BARRETT, RW
DOWER, WJ
FODOR, SPA
GALLOP, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) : 1385 - 1401
[4] Heck R.F., 1991, COMPREHENSIVE ORGANI, V4, P833, DOI DOI 10.1016/B978-0-08-052349-1.00110-4
[5] PALLADIUM-CATALYZED VINYLATION OF ORGANIC HALIDES UNDER SOLID LIQUID-PHASE TRANSFER CONDITIONS
JEFFERY, T
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (19) : 1287 - 1289
[6] HIGHLY STEREOSPECIFIC PALLADIUM-CATALYZED VINYLATION OF VINYLIC HALIDES UNDER SOLID-LIQUID PHASE-TRANSFER CONDITIONS
JEFFERY, T
[J]. TETRAHEDRON LETTERS, 1985, 26 (22) : 2667 - 2670
[7] HECK-TYPE REACTIONS IN WATER
JEFFERY, T
[J]. TETRAHEDRON LETTERS, 1994, 35 (19) : 3051 - 3054
[8] RAPP W, 1991, 2ND P S INN PERSP SO
[9] HECK REACTIONS IN SOLID-PHASE SYNTHESIS
YU, KL
DESHPANDE, MS
VYAS, DM
[J]. TETRAHEDRON LETTERS, 1994, 35 (48) : 8919 - 8922

← 1 →