GLIBENCLAMIDE DEPRESSES THE SLOWLY INACTIVATING OUTWARD CURRENT (ID) IN HIPPOCAMPAL-NEURONS

被引：18

作者：

CREPEL, V

KRNJEVIC, K

BENARI, Y

机构：

[1] INSERM,U29,F-75614 PARIS 14,FRANCE

[2] MCGILL UNIV,ANAESTHESIA RES DEPT,MONTREAL H3G 1Y6,QUEBEC,CANADA

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1992年 / 70卷 / 02期

关键词：

GLIBENCLAMIDE; GLIQUIDONE; TOLBUTAMIDE; K-CURRENTS; RAT HIPPOCAMPAL SLICES;

D O I：

10.1139/y92-038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sulphonylurea drugs, such as glibenclamide and tolbutamide, are widely used as selective blockers of adenosine triphosphate-sensitive K channels. In experiments on hippocampal slices (from Wistar rats) glibenclamide (and possibly gliquidone and tolbutamide) significantly reduced the highly voltage-dependent, 4-aminopyridine-sensitive D-type outward current of CA3 neurons. Judging by these observations, the sulphonylureas may not be as selective as generally believed.

引用

页码：306 / 307

页数：2

共 9 条

[1] GALANIN AND GLIBENCLAMIDE MODULATE THE ANOXIC RELEASE OF GLUTAMATE IN RAT CA3 HIPPOCAMPAL-NEURONS [J].