DIAMINOALKANES WITH AN ODD NUMBER OF CARBON-ATOMS INDUCE COMPACTION OF A SINGLE DOUBLE-STRANDED DNA CHAIN

被引：63

作者：

YOSHIKAWA, Y ^{[1
]}

YOSHIKAWA, K ^{[1
]}

机构：

[1] NAGOYA UNIV,GRAD SCH HUMAN INFORMAT,DIV INFORMAT NAT SCI,NAGOYA,AICHI 46401,JAPAN

来源：

FEBS LETTERS | 1995年 / 361卷 / 2-3期

关键词：

DIAMINOALKANE; HIGHER ORDER STRUCTURE OF DNA; GLOBULAR DNA; SINGLE MOLECULAR OBSERVATION;

D O I：

10.1016/0014-5793(95)00190-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have performed direct observations on the conformational change of a single double-stranded T4 DNA molecule induced by diaminoalkanes, NH3+(CH2)(n)NH3+ (n = 1 similar to 6), by use of fluorescence microscopy, It was found that diamines with three and five methylene groups show a significant effect on the compaction of individual single DNA molecules, On the other hand, diamines with two, four and six methylene groups are not effective in the compaction of DNA, Such a drastic difference in the action of diamines suggests that not only the number of charge but also the length between the amino groups in the diamines plays an essential role in their interactions with DNA.

引用

页码：277 / 281

页数：5

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