HYPOLIPIDEMIC EFFECTS IN MONKEYS OF ML-236B, A COMPETITIVE INHIBITOR OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE

被引:68
作者
KURODA, M [1 ]
TSUJITA, Y [1 ]
TANZAWA, K [1 ]
ENDO, A [1 ]
机构
[1] SANKYO CO LTD,FERMENTAT RES LABS,1-2-58 HIRO,SHINAGAWA KU,TOKYO 140,JAPAN
关键词
D O I
10.1007/BF02533537
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The fungal metabolite ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, has been shown to be significantly effective in lowering serum cholesterol levels in cynomolgus monkeys at doses of 20-50 mg/kg per day. Levels of serum phospholipids and triglycerides were, however, not significantly changed by the administration of the drug. Of the serum lipoprotein fractions, a β-lipoprotein corresponding to low density lipoprotein was preferentially reduced by the drug treatment. Fecal excretion of neutral sterols was unaffected but that of bile acids was slightly elevated by the administration of ML-236B. © 1979 American Oil Chemists' Society.
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页码:585 / 589
页数:5
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