EFFECTS OF THIOPHENE ON THE PURKINJE-CELL DENDRITIC TREE - QUANTITATIVE GOLGI STUDY

Bradley P. & Berry M. (1979) Neuropathology and Applied Neurobiology5, 9–16 Effects of thiophene on the Purkinje cell dendritic tree: a quantitative Golgi study A quantitative analysis was made of alterations in the dendritic organisation of Purkinje cells in the cerebellum of the adult rat following the administration of the degranulating agent, thiophene. This substance completely eliminated the granule cell population in a number of regions of cerebellar cortex. Purkinje cell dendritic trees in these regions were markedly reduced in size when compared with control cells and provided evidence for a non‐random loss of dendritic segments. Other dendritic abnormalities were noted. These results were discussed in relation to current theories of neuronal maintenance, and the feasibility of using toxic degranulating agents, such as thiophene, was considered. Copyright © 1979, Wiley Blackwell. All rights reserved