EFFECTS OF THIOPHENE ON THE PURKINJE-CELL DENDRITIC TREE - QUANTITATIVE GOLGI STUDY

被引：8

作者：

BRADLEY, P ^{[1
]}

BERRY, M ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,DEPT ANAT,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1979年 / 5卷 / 01期

关键词：

D O I：

10.1111/j.1365-2990.1979.tb00609.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Bradley P. & Berry M. (1979) Neuropathology and Applied Neurobiology5, 9–16 Effects of thiophene on the Purkinje cell dendritic tree: a quantitative Golgi study A quantitative analysis was made of alterations in the dendritic organisation of Purkinje cells in the cerebellum of the adult rat following the administration of the degranulating agent, thiophene. This substance completely eliminated the granule cell population in a number of regions of cerebellar cortex. Purkinje cell dendritic trees in these regions were markedly reduced in size when compared with control cells and provided evidence for a non‐random loss of dendritic segments. Other dendritic abnormalities were noted. These results were discussed in relation to current theories of neuronal maintenance, and the feasibility of using toxic degranulating agents, such as thiophene, was considered. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：9 / 16

页数：8

共 30 条

[11]

COLEMAN PD, 1968, J ANAT, V102, P363

[12]

COLONNIER M, 1964, J ANAT, V98, P47

[13] EFFECTS OF ENVIRONMENT ON MORPHOLOGY OF RAT CEREBRAL-CORTEX AND HIPPOCAMPUS [J].

DIAMOND, MC ;

INGHAM, CA ;

JOHNSON, RE ;

BENNETT, EL ;

ROSENZWEIG, MR .

JOURNAL OF NEUROBIOLOGY, 1976, 7 (01) :75-85

[14]

GELFAN S, 1972, J COMP NEUROLOGY, V123, P73

[15] DEGENERATIVE CHANGES IN DENDRITES CENTRAL TO AXONAL TRANSECTION . ELECTRON MICROSCOPICAL OBSERVATIONS [J].

GRANT, G ;

WESTMAN, J .

EXPERIENTIA, 1968, 24 (02) :169-&

[16]

GRANT G, 1975, ADV NEUROL, V12, P373

[17]

GRAY EG, 1966, HEAD INJURY C P

[18]

HERNDON RM, 1968, EXP BRAIN RES, V6, P49

[19] ELECTRON-MICROSCOPIC STUDY OF CYCASIN-INDUCED CEREBELLAR ALTERATIONS [J].

HIRANO, A ;

JONES, M ;

DEMBITZER, HM .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1972, 31 (01) :113-+

[20]

JONES WH, 1962, J ANAT, V96, P375

← 1 2 3 →