DOSE-RESPONSE EFFECTS OF 2 SIZES OF MONODISPERSE ISOPROTERENOL IN MILD ASTHMA

被引:25
作者
PATEL, P [1 ]
MUKAI, D [1 ]
WILSON, AF [1 ]
机构
[1] UNIV CALIF IRVINE,IRVINE MED CTR,DEPT MED,101 CITY DR S,ORANGE,CA 92668
来源
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1990年 / 141卷 / 02期
关键词
D O I
10.1164/ajrccm/141.2.357
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The dose-response effect of monodispersed isoproterenol of two different sizes (diameters 2.5 and 5 μm) was examined in eight mild asthmatic subjects (baseline FEV1 81.5% of predicted). Pulmonary and cardiovascular variables were measured before and following 1, 2, 4, 8, and 16 cumulative min of aerosol inhalation. Subjects inhaled 1 to 30 μg (2.5-μm particles) or 2 to 50 μg (5-μm particles) of isoproterenol. Pulmonary but not cardiac responses were significantly greater for the 2.5-μm particles as compared to equivalent doses of 5-μm particles. Pulmonary dose-related response differences were particularly marked for variables associated with small airway function (FEF25-75 and FEF75-85). These findings suggest that small particles penetrate more deeply into the lung and thereby more effectively dilate small airways and that small amounts of appropriately sized inhaled bronchodilator may produce considerable therapeutic effects.
引用
收藏
页码:357 / 360
页数:4
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