NATURAL CYTOTOXIC-CELLS IN NZB MICE - SPONTANEOUS INVIVO AND INVITRO PRIMED ACTIVITY AND STRUCTURAL CHARACTERISTICS

被引：4

作者：

CROKER, BP ^{[1
]}

ZINKERNAGEL, RM ^{[1
]}

DIXON, FJ ^{[1
]}

机构：

[1] SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0090-1229(79)90046-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The natural cytotoxic activity of spleen cells from NZB mice was within the same range as those from 17 other murine strains. In vivo priming with a syngeneic lymphoma cell line, but not with murine leukemia virus (MuLV), stimulated T cells and also N cells, which are responsible for the natural cytotoxic activity. In vitro stimulation in this system resulted in an intense increase in N-cell activity and permitted isolation of a highly uniform population of cells. Marked differences were noted in the lysis target of cells of different types, but there was no relationship to MuLV expression by the targets. © 1979.

引用

页码：410 / 424

页数：15

共 34 条

[1] T-LYMPHOCYTE RESPONSE TO FRIEND VIRUS-INDUCED TUMOR-CELL LINES IN MICE OF STRAINS CONGENIC AT H-2 [J].

BLANK, KJ ;

FREEDMAN, HA ;

LILLY, F .

NATURE, 1976, 260 (5548) :250-252

[2]

BOLZENHARDT V, 1978, J EXP MED, V147, P1435

[3] STUDIES ON ROLE OF HOST IMMUNE-RESPONSE IN RECOVERY FROM FRIEND VIRUS LEUKEMIA .2. CELL-MEDIATED-IMMUNITY [J].

CHESEBRO, B ;

WEHRLY, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 143 (01) :85-99

[4] T-LYMPHOCYTE REQUIREMENT FOR MSV TUMOR PREVENTION OR REGRESSION [J].

COLLAVO, D ;

COLOMBATTI, A ;

CHIECOBI.L ;

DAVIES, AJS .

NATURE, 1974, 249 (5453) :169-170

[5] IMMUNOPATHOGENICITY AND ONCOGENICITY OF MURINE LEUKEMIA VIRUSES .1. INDUCTION OF IMMUNOLOGICAL DISEASE AND LYMPHOMA IN (BALB-C XNZB)F1 MICE BY SCRIPPS LEUKEMIA-VIRUS [J].

CROKER, BP ;

DELVILLA.BC ;

JENSEN, FC ;

LERNER, RA ;

DIXON, FJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1974, 140 (04) :1028-1048

[6] IMMUNO-PATHOGENICITY AND ONCOGENICITY OF MURINE LEUKEMIA-VIRUS .3. QUANTITATION OF SPONTANEOUS VIRUS EXPRESSION [J].

CROKER, BP ;

MCCONAHEY, PJ ;

MURPHY, ED ;

DIXON, FJ .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (01) :199-205

[7] ONCORNAVIRUS GLYCOPROTEIN GP69-71 - CONSTITUENT OF SURFACE OF NORMAL AND MALIGNANT THYMOCYTES [J].

DELVILLANO, BC ;

NAVE, B ;

CROKER, BP ;

LERNER, RA ;

DIXON, FJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1975, 141 (01) :172-187

[8]

GERMAIN RN, 1976, AM J PATHOL, V85, P661

[9] IDENTIFICATION OF A CELL-SURFACE ANTIGEN SELECTIVELY EXPRESSED ON NATURAL KILLER CELL [J].

GLIMCHER, L ;

SHEN, FW ;

CANTOR, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 145 (01) :1-9

[10]

GREENBERG AH, 1973, CLIN EXP IMMUNOL, V15, P445

← 1 2 3 4 →