SEPARATION OF POLYMYXINS AND OCTAPEPTINS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：29

作者：

TERABE, S ^{[1
]}

KONAKA, R ^{[1
]}

SHOJI, J ^{[1
]}

机构：

[1] SHIONOGI & CO LTD,RES LAB,OSAKA 553,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 173卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(00)92299-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Seventeen decapeptide antibiotics of the polymyxin group and nine octapeptide antibiotics of the octapeptin group have been successfully separated on a commercial reversed-phase material with tartrate buffer-acetonitrile containing sodium 1-butanesulphonate and sodium sulphate as the mobile phase. All of the components of EM49 (a complex of octapeptins A and B) were preparatively separated by use of a large-diameter column, and the structures of two new components, named octapeptins A4 and B4, were deduced from the results of the fatty acid and amino acid analyses. © 1979.

引用

页码：313 / 320

页数：8

共 21 条

[1] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF GRAMICIDIN, A POLYPEPTIDE ANTIBIOTIC [J].