CROSS-SPECIES COMPLEMENTATION OF THE INDISPENSABLE ESCHERICHIA-COLI ERA GENE HIGHLIGHTS AMINO-ACID REGIONS ESSENTIAL FOR ACTIVITY

被引:29
作者
PILLUTLA, RC
SHARER, JD
GULATI, PS
WU, E
YAMASHITA, Y
LERNER, CG
INOUYE, M
MARCH, PE
机构
[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,PISCATAWAY,NJ 08854
[2] DANA FARBER CANC INST,BOSTON,MA 02115
[3] KYUSHU UNIV,DEPT PREVENT DENT,HIGASHI KU,FUKUOKA 812,JAPAN
关键词
D O I
10.1128/jb.177.8.2194-2196.1995
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Era is an essential GTP binding protein in Escherichia coli. Two homologs of this protein, Sgp from Streptococcus mutans and Era from Coxiella burnetii, can substitute for the essential function of Era in E. coli. Site-specific and randomly generated Era mutants which may indicate regions of the protein that are of functional importance are described.
引用
收藏
页码:2194 / 2196
页数:3
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