IDENTIFICATION OF HERPESVIRUS-LIKE DNA-SEQUENCES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA

被引：4663

作者：

CHANG, Y

CESARMAN, E

PESSIN, MS

LEE, F

CULPEPPER, J

KNOWLES, DM

MOORE, PS

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,DEPT BIOL MOLEC,PALO ALTO,CA 94304

[2] NEW YORK CITY DEPT HLTH,DIS INTERVENT COMMISS,NEW YORK,NY 10013

[3] COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL,NEW YORK,NY 10013

来源：

SCIENCE | 1994年 / 266卷 / 5192期

关键词：

D O I：

10.1126/science.7997879

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Representational difference analysis was used lo isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.

引用

页码：1865 / 1869

页数：5