PREPARATION OF OPTICALLY-ACTIVE 4-ALLYLAZETIDIN-2-ONES - AN ACCESS TO CARBACEPHAMS

被引：12

作者：

OUMOCH, S ^{[1
]}

ROUSSEAU, G ^{[1
]}

机构：

[1] UNIV PARIS 11,INST CHIM MOLEC ORSAY,CARBOCYCLES LAB,CNRS,URA 478,F-91405 ORSAY,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)80825-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Transesterification of 4-allyl-1-hydroxymethylazetidin-2-ones using vinyl acetate in the presence of the lipase from Pseudomonas cepacia led to the corresponding (R)-acetates and the remaining (S)-alcohols in high yields and excellent ee's (E : 32-71). Subsequent reaction with BF3-Et(2)O can lead to the carbacepham framework.

引用

页码：2841 / 2844

页数：4

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