INCORPORATION OF CRYSTALLOGRAPHIC TEMPERATURE FACTORS IN THE STATISTICAL-ANALYSIS OF PROTEIN TERTIARY STRUCTURES

被引：19

作者：

BOTT, R ^{[1
]}

FRANE, J ^{[1
]}

机构：

[1] GENENTECH INC, SAN FRANCISCO, CA 94080 USA

来源：

PROTEIN ENGINEERING | 1990年 / 3卷 / 08期

关键词：

Site-specific variant structure; X-ray crystallography;

D O I：

10.1093/protein/3.8.649

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A method to identify statistically significant differences between equivalent atoms in two closely related protein X-ray crystallographic structures is described. This method uses the linear relationship found between the logarithm of the distance between equivalent atoms and their mean temperature factor to determine, by linear regression, the expected difference and variance. © 1990 Oxford University Press.

引用

页码：649 / 657

页数：9

共 15 条

[11] REFINED CRYSTAL-STRUCTURE OF GAMMA-CHYMOTRYPSIN AT 1.9 A RESOLUTION - COMPARISON WITH OTHER PANCREATIC SERINE PROTEASES [J].