BRAIN MONOAMINE-OXIDASE AND AGING - A REVIEW

被引：8

作者：

BURCHINSKY, SG

KUZNETSOVA, SM

机构：

[1] Institute of Gerontology, USSR Academy of Medical Sciences, 252655 Kiev -114

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1992年 / 14卷 / 01期

关键词：

MONOAMINE OXIDASE; PARKINSONISM; MPTP; BRAIN AGING;

D O I：

10.1016/0167-4943(92)90002-L

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The present state of research on the age-related dynamics of brain monoamine oxidase (MAO) activity and its role in the development of age pathology is described. Special attention is given to the role of MAO in the pathogenesis of parkinsonism and to the mechanisms of its interaction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a possible etiological factor of parkinsonism development in aging. The mechanisms of action of the selective MAO-B inhibitor, deprenyl, and their peculiarities in old age are analyzed. This study provides evidence pointing to a need for the use of deprenyl in geriatric practice as an effective drug for parkinsonism treatment and as a potent geroprotector.

引用

页码：1 / 15

页数：15

共 107 条

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