STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .5. 9-DEAZAHYPOXANTHINES

被引：24

作者：

NIWAS, S

CHAND, P

PATHAK, VP

MONTGOMERY, JA

机构：

[1] SO RES INST,BIRMINGHAM,AL 35255

[2] BIOCRYST PHARMACEUT INC,BIRMINGHAM,AL 35244

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 15期

关键词：

D O I：

10.1021/jm00041a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.

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页码：2477 / 2480

页数：4

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