STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .2. 9-ALICYCLIC AND 9-HETEROALICYCLIC DERIVATIVES OF 9-DEAZAGUANINE

被引：48

作者：

SECRIST, JA

NIWAS, S

ROSE, JD

BABU, YS

BUGG, CE

ERION, MD

GUIDA, WC

EALICK, SE

MONTGOMERY, JA

机构：

[1] BIOCRYST PHARMACEUT INC,2190 PKWY LAKE DR,BIRMINGHAM,AL 35244

[2] SO RES INST,BIRMINGHAM,AL 35255

[3] CIBA GEIGY CORP,SUMMIT,NJ 07901

[4] UNIV ALABAMA,BIRMINGHAM,AL 35294

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 13期

关键词：

D O I：

10.1021/jm00065a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5-dihydro-4H-pyrrolo[3,2-d][pyrimidin-4-one) d] [pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives previously investigated. The mode of binding of these compounds to PNP was determined by X-ray crystallography.

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页码：1847 / 1854

页数：8

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