INDUCTION OF D2-DOPAMINE RECEPTOR MESSENGER-RNA SYNTHESIS IN A 6-HYDROXYDOPAMINE PARKINSONIAN RAT MODEL

被引:18
作者
LISOVOSKI, F
HABY, C
BORRELLI, E
SCHLEEF, C
REVEL, MO
HINDELANG, C
ZWILLER, J
机构
[1] CTR NEUROCHIM,INSERM,U338,5 RUE BLAISE PASCAL,F-67084 STRASBOURG,FRANCE
[2] LAB GENET MOLEC EUCARYOTES,CNRS,F-67085 STRASBOURG,FRANCE
[3] CTR NEUROCHIM,CNRS,F-67084 STRASBOURG,FRANCE
[4] LAB PHYSIOL,CNRS,URA 309,F-67084 STRASBOURG,FRANCE
关键词
DOPAMINE D2 RECEPTOR MESSENGER RNA; PARKINSONIAN;
D O I
10.1016/0361-9230(92)90248-V
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
By injecting 6-hydroxydopamine into the pars compacta of the substantia nigra, we produced a hemiparkinsonian rat model in which there is almost complete destruction of the dopaminergic nigrostriatal pathway but sparing of the dopaminergic mesolimbic system. The lesion has been characterized by several criteria: a rotational behavior in response to apomorphine, a complete loss of tyrosine hydroxylase immunoreactivity in the lesioned substantia nigra, a near total depletion of dopamine and metabolites in the striatum ipsilateral to the lesion, and a supersensitivity of the dopamine D2 receptors in the ipsilateral striatum. Dopaminergic striatal deefferentation was accompanied by an increase of D2 receptor mRNA synthesis in the striatum ipsilateral to the lesion, suggesting that the increased D2 receptor density observed after the lesion is due to an increase of the synthesis of receptor molecules. This synthesis appears to be regulated at the transcriptional level.
引用
收藏
页码:697 / 701
页数:5
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