A FAMILY OF METABOTROPIC GLUTAMATE RECEPTORS

被引：958

作者：

TANABE, Y ^{[1
]}

MASU, M ^{[1
]}

ISHII, T ^{[1
]}

SHIGEMOTO, R ^{[1
]}

NAKANISHI, S ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT MORPHOL BRAIN SCI,KYOTO 606,JAPAN

来源：

NEURON | 1992年 / 8卷 / 01期

关键词：

D O I：

10.1016/0896-6273(92)90118-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Three cDNA clones, mGluR2, mGluR3, and mGLuR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.

引用

页码：169 / 179

页数：11

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