A FAMILY OF METABOTROPIC GLUTAMATE RECEPTORS

被引：958

作者：

TANABE, Y ^{[1
]}

MASU, M ^{[1
]}

ISHII, T ^{[1
]}

SHIGEMOTO, R ^{[1
]}

NAKANISHI, S ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT MORPHOL BRAIN SCI,KYOTO 606,JAPAN

来源：

NEURON | 1992年 / 8卷 / 01期

关键词：

D O I：

10.1016/0896-6273(92)90118-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Three cDNA clones, mGluR2, mGluR3, and mGLuR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.

引用

页码：169 / 179

页数：11

共 39 条

[31] THE TESTICULAR RECEPTOR FOR FOLLICLE-STIMULATING-HORMONE - STRUCTURE AND FUNCTIONAL EXPRESSION OF CLONED CDNA [J].

SPRENGEL, R ;

BRAUN, T ;

NIKOLICS, K ;

SEGALOFF, DL ;

SEEBURG, PH .

MOLECULAR ENDOCRINOLOGY, 1990, 4 (04) :525-530

[32] STIMULATION OF CAMP FORMATION BY PROSTAGLANDIN-D2 IN PRIMARY CULTURES OF BOVINE ADRENAL-MEDULLARY CELLS - IDENTIFICATION OF THE RESPONSIVE POPULATION AS FIBROBLASTS [J].

SUGAMA, K ;

TANAKA, T ;

YOKOHAMA, H ;

NEGISHI, M ;

HAYASHI, H ;

ITO, S ;

HAYAISHI, O .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1011 (01) :75-80

[33] A NEW TYPE OF GLUTAMATE RECEPTOR LINKED TO INOSITOL PHOSPHOLIPID-METABOLISM [J].

SUGIYAMA, H ;

ITO, I ;

HIRONO, C .

NATURE, 1987, 325 (6104) :531-533

[34] GLUTAMATE RECEPTOR SUBTYPES MAY BE CLASSIFIED INTO 2 MAJOR CATEGORIES - A STUDY ON XENOPUS OOCYTES INJECTED WITH RAT-BRAIN MESSENGER-RNA [J].

SUGIYAMA, H ;

ITO, I ;

WATANABE, M .

NEURON, 1989, 3 (01) :129-132

[35] STRUCTURE AND FUNCTIONAL EXPRESSION OF THE CLONED RAT NEUROTENSIN RECEPTOR [J].

TANAKA, K ;

MASU, M ;

NAKANISHI, S .

NEURON, 1990, 4 (06) :847-854

[36] ISLET-ACTIVATING PROTEIN, PERTUSSIS TOXIN - A PROBE FOR FUNCTIONS OF THE INHIBITORY GUANINE-NUCLEOTIDE REGULATORY COMPONENT OF ADENYLATE-CYCLASE [J].

UI, M .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1984, 5 (07) :277-279

[37] ISOLATION OF CHINESE-HAMSTER CELL MUTANTS DEFICIENT IN DIHYDROFOLATE-REDUCTASE ACTIVITY [J].

URLAUB, G ;

CHASIN, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :4216-4220

[38]

VONHEIJNE G, 1983, EUR J BIOCHEM, V133, P17

[39]

WONG SKF, 1990, J BIOL CHEM, V265, P6219

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