DETERMINATION OF PENICILLAMINE OR TIOPRONIN IN PHARMACEUTICAL PREPARATIONS BY FLOW-INJECTION ANALYSIS

被引：34

作者：

GARCIA, MS ^{[1
]}

SANCHEZPEDRENO, C ^{[1
]}

ALBERO, MI ^{[1
]}

RODENAS, V ^{[1
]}

机构：

[1] UNIV MURCIA,FAC CHEM,DEPT ANALYT CHEM,E-30071 MURCIA,SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 08期

关键词：

PENICILLAMINE; TIOPRONIN; PALLADIUM (II); FIA; PHARMACEUTICAL PREPARATIONS;

D O I：

10.1016/0731-7085(93)80168-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two flow injection analysis (FIA) methods, using spectrophotometric detection, are proposed for the determination of penicillamine or tiopronin [N-(2-mercaptopropionylglycine)]. The procedures are based on the formation of yellow complexes between these thiol-containing drugs and Pd(II), in a 1 M or 0.25 M HCl medium, respectively. With peak height as a quantitative parameter, penicillamine is determined over the range 1.0 x 10(-5)-7.0 x 10(-4) M; for tiopronin the range is 1.0 x 10(-5)-6.0 x 10(-4) M. The methods have been applied to the routine determination of the drugs in pharmaceutical preparations.

引用

页码：633 / 638

页数：6

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