DETERMINATION OF PENICILLAMINE OR TIOPRONIN IN PHARMACEUTICAL PREPARATIONS BY FLOW-INJECTION ANALYSIS

被引：34

作者：

GARCIA, MS ^{[1
]}

SANCHEZPEDRENO, C ^{[1
]}

ALBERO, MI ^{[1
]}

RODENAS, V ^{[1
]}

机构：

[1] UNIV MURCIA,FAC CHEM,DEPT ANALYT CHEM,E-30071 MURCIA,SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 08期

关键词：

PENICILLAMINE; TIOPRONIN; PALLADIUM (II); FIA; PHARMACEUTICAL PREPARATIONS;

D O I：

10.1016/0731-7085(93)80168-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two flow injection analysis (FIA) methods, using spectrophotometric detection, are proposed for the determination of penicillamine or tiopronin [N-(2-mercaptopropionylglycine)]. The procedures are based on the formation of yellow complexes between these thiol-containing drugs and Pd(II), in a 1 M or 0.25 M HCl medium, respectively. With peak height as a quantitative parameter, penicillamine is determined over the range 1.0 x 10(-5)-7.0 x 10(-4) M; for tiopronin the range is 1.0 x 10(-5)-6.0 x 10(-4) M. The methods have been applied to the routine determination of the drugs in pharmaceutical preparations.

引用

页码：633 / 638

页数：6

共 25 条

[21] SENSITIVE DERIVATIZATION REAGENTS FOR THIOL COMPOUNDS IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION [J].

SHIMADA, K ;

TANAKA, M ;

NAMBARA, T .

ANALYTICA CHIMICA ACTA, 1983, 147 (MAR) :375-380

[22] MANUAL AND FLOW-INJECTION SPECTROPHOTOMETRIC ASSAY OF THIOLS, BASED ON THEIR S-NITROSATION [J].

VERMA, KK ;

STEWART, KK ;

JAIN, A ;

GUPTA, D ;

SANGHI, SK .

TALANTA, 1991, 38 (03) :283-289

[23] FLOW-INJECTION ANALYSIS AND BATCH PROCEDURES FOR THE ROUTINE DETERMINATION OF N-PENICILLAMINE [J].

VINAS, P ;

SANCHEZPRIETO, JA ;

CORDOBA, MH .

MICROCHEMICAL JOURNAL, 1990, 41 (01) :2-9

[24]

VOLLMER PJ, 1980, J ASSOC OFF ANA CHEM, V63, P1191

[25]

WINDHOLZ M, 1983, MERCK INDEX, P1355

← 1 2 3 →