CHARACTERIZATION OF 10 NEW POLYMORPHIC DINUCLEOTIDE REPEATS AND GENERATION OF A HIGH-DENSITY MICROSATELLITE-BASED PHYSICAL MAP OF THE BRCA1 REGION OF CHROMOSOME-17Q21

被引：10

作者：

COUCH, FJ

KIOUSIS, S

CASTILLA, LH

XU, JH

CHANDRASEKHARAPPA, SC

CHAMBERLAIN, JS

COLLINS, FS

WEBER, BL

机构：

[1] UNIV PENN,DEPT INTERNAL MED,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT GENET,PHILADELPHIA,PA 19104

[3] UNIV MICHIGAN,SCH MED,DEPT HUMAN GENET,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,CTR HUMAN GENOME,ANN ARBOR,MI 48109

[5] NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892

来源：

GENOMICS | 1994年 / 24卷 / 03期

关键词：

D O I：

10.1006/geno.1994.1647

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs. (C) 1994 Academic Press,Inc.

引用

页码：419 / 424

页数：6

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