DIAGNOSTIC-VALUE OF ANTINEURONAL ANTIBODIES FOR PARANEOPLASTIC DISORDERS OF THE NERVOUS-SYSTEM

被引:36
作者
MOLL, JWB
HENZENLOGMANS, SC
SPLINTER, TAW
VANDERBURG, MEL
VECHT, CJ
机构
[1] DR DANIEL DEN HOED CANC CTR,DEPT NEUROL,3075 EA ROTTERDAM,NETHERLANDS
[2] DR DANIEL DEN HOED CANC CTR,DEPT PATHOL,3075 EA ROTTERDAM,NETHERLANDS
[3] DR DANIEL DEN HOED CANC CTR,DEPT MED ONCOL,3075 EA ROTTERDAM,NETHERLANDS
[4] ERASMUS UNIV,HOSP DIJKZIGT,DEPT NEUROL,ROTTERDAM,NETHERLANDS
[5] ERASMUS UNIV,HOSP DIJKZIGT,DEPT MED ONCOL,ROTTERDAM,NETHERLANDS
关键词
D O I
10.1136/jnnp.53.11.940
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The diagnostic value of the presence of anti-neuronal antibodies in serum was examined in 21 patients suspected of paraneoplastic disorders of the nervous system (NS) (group 1) and was compared to three control groups; group 2: 25 patients with a neurological disease, without cancer and no signs of paraneoplastic disorder; group 3: 27 patients with neurological disease and cancer and no signs of a paraneoplastic disorder; group 4: 94 patients with cancer and without neurological disease. In group 1, anti-neuronal nuclear antibodies were detected in eight patients (38%), in titres from 1:1000 to 1:32 000. A small cell lung cancer was present in six patients, ovarian cancer in one patient and in one patient no tumour could be detected. The neurological symptoms preceded a diagnosis of cancer in five out of eight patients. Anti-neuronal antibodies were found in the serum of two out of 94 patients (2%) from control group 3 but not in serum from any of the other control groups. These data indicate a moderate sensitivity of 38%, but a high specificity of 98-6% (95% confidence interval 95-5-99-8%) for the presence of anti-neuronal nuclear antibodies if a paraneoplastic NS disorder is suspected.
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页码:940 / 943
页数:4
相关论文
共 12 条
[1]   PARA-NEOPLASTIC CEREBELLAR DEGENERATION - CLINICAL-IMMUNOLOGICAL CORRELATIONS [J].
ANDERSON, NE ;
ROSENBLUM, MK ;
POSNER, JB .
ANNALS OF NEUROLOGY, 1988, 24 (04) :559-567
[2]   AUTOANTIBODIES IN PARA-NEOPLASTIC SYNDROMES ASSOCIATED WITH SMALL-CELL LUNG-CANCER [J].
ANDERSON, NE ;
ROSENBLUM, MK ;
GRAUS, F ;
WILEY, RG ;
POSNER, JB .
NEUROLOGY, 1988, 38 (09) :1391-1398
[3]   ENCEPHALOMYELONEUROPATHY IN THE ABSENCE OF A DETECTABLE NEOPLASM - CLINICAL AND POSTMORTEM FINDINGS IN 3 CASES [J].
DANIEL, SE ;
LOVE, S ;
SCARAVILLI, F ;
HARDING, AE .
ACTA NEUROPATHOLOGICA, 1985, 66 (04) :311-317
[4]  
GRAUYGRAUS F, 1986, AM J MED, V180, P45
[5]   ANTIBODIES TO CEREBELLAR PURKINJE-CELLS IN PATIENTS WITH PARA-NEOPLASTIC CEREBELLAR DEGENERATION AND OVARIAN-CARCINOMA [J].
GREENLEE, JE ;
BRASHEAR, HR .
ANNALS OF NEUROLOGY, 1983, 14 (06) :609-613
[6]   ANTINEURONAL ANTIBODIES IN SMALL CELL LUNG-CARCINOMA - A SIGNIFICANCE FOR PARA-NEOPLASTIC SYNDROMES [J].
GRISOLD, W ;
DRLICEK, M ;
POPP, W ;
JELLINGER, K .
ACTA NEUROPATHOLOGICA, 1987, 75 (02) :199-202
[7]  
HENSON RA, 1982, CANCER NERVOUS SYSTE
[8]   AUTOIMMUNE-RESPONSE OF PATIENTS WITH PARA-NEOPLASTIC CEREBELLAR DEGENERATION TO A PURKINJE-CELL CYTOPLASMIC PROTEIN ANTIGEN [J].
JAECKLE, KA ;
GRAUS, F ;
HOUGHTON, A ;
CARDONCARDO, C ;
NIELSEN, SL ;
POSNER, JB .
ANNALS OF NEUROLOGY, 1985, 18 (05) :592-600
[9]   SUBACUTE SENSORY NEURONOPATHY SECONDARY TO DORSAL-ROOT GANGLIONITIS IN PRIMARY SJOGRENS-SYNDROME [J].
MALINOW, K ;
YANNAKAKIS, GD ;
GLUSMAN, SM ;
EDLOW, DW ;
GRIFFIN, J ;
PESTRONK, A ;
POWELL, DL ;
RAMSEYGOLDMAN, R ;
EIDELMAN, BH ;
MEDSGER, TA ;
ALEXANDER, EL .
ANNALS OF NEUROLOGY, 1986, 20 (04) :535-537
[10]   ANTINEURONAL ANTIBODIES IN PARANEOPLASTIC NEUROLOGICAL DISORDERS WITH SMALL-CELL LUNG-CARCINOMA [J].
MOLL, JWB ;
HENZENLOGMANS, SC ;
VECHT, CJ .
CLINICAL NEUROLOGY AND NEUROSURGERY, 1990, 92 (03) :223-228