TOXICOLOGICAL STUDIES ON A BENZOFURANE DERIVATIVE .2. DEMONSTRATION OF PEROXISOME PROLIFERATION IN RAT-LIVER

被引：14

作者：

BUTLER, EG ^{[1
]}

ICHIDA, T ^{[1
]}

MARUYAMA, H ^{[1
]}

SCHULTEHERMANN, R ^{[1
]}

WILLIAMS, GM ^{[1
]}

机构：

[1] AMER HLTH FDN,1 DANA RD,VALHALLA,NY 10595

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1990年 / 106卷 / 03期

关键词：

D O I：

10.1016/0041-008X(90)90344-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The uricosuric drug benzbromarone (3,5-dibromo-4-hydroxyphenyl)-1-(2-ethyl-3-benzofuranyl)methanone, a benzofurane derivative, was studied for its effects on parameters related to hepatic peroxisome proliferation. Groups of male F-344 rats were fed either basal diet, the peroxisome proliferator clofibrate at 5000 ppm as a comparison compound, or benzbromarone at two doses, 1000 and 2000 ppm. Benzbromarone and clofibrate produced hepatomegaly and increases in the activities of catalase, acyl CoA oxidase, malate dehydrogenase, and glycerol-3-phosphate dehydrogenase. Benzbromarone and clofibrate also both induced similar histologic and ultrastructural changes in hepatocytes, including induction of peroxisomes. Therefore, benzbromarone acted as a peroxisome-proliferating agent in rats under these conditions. Benzbromarone differs from other peroxisome proliferators in its chemical structure, uricosuric action, and the morphology of liver peroxisomes that were induced by exposure. © 1990.

引用

页码：500 / 508

页数：9