ANTISENSE OLIGONUCLEOTIDES AS ANTIVIRAL AGENTS

被引：120

作者：

AGRAWAL, S

机构：

[1] Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545

来源：

TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 05期

关键词：

D O I：

10.1016/0167-7799(92)90203-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antisense oligonucleotides we an attractive potential alternative to conventional drugs as antiviral agents. A major advantage is the relatively simple rational design of oligonucleotides which should bind only to specific nucleic acid sequences, compared with conventional drugs which are frequently targeted against sites of unknown structure in proteins. Progress to date provides hope for the development of a new class of antiviral chemotherapeutics based on antisense oligonucleotides.

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页码：152 / 158

页数：7

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