ENZYMATIC-HYDROLYSIS OF HETEROCYCLIC NITRILES

被引:19
作者
KLEMPIER, N
DERAADT, A
GRIENGL, H
HEINISCH, G
机构
[1] GRAZ TECH UNIV, INST ORGAN CHEM, A-8010 GRAZ, AUSTRIA
[2] UNIV INNSBRUCK, INST ORGAN & PHARMACEUT CHEM, A-6020 INNSBRUCK, AUSTRIA
关键词
D O I
10.1002/jhet.5570290115
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp. Pyrimidine-2-carbonitrile (2a) and 3-chloropyridazine-4-carbonitrile (4a) were converted into the corresponding amides while from 2-ethoxycarbonyl-4-pyridinecarbonitrile (1a), 6-methylpyridazine-3-carbonitrile (3a), 3-chloropyridazine-4-carbonitrile (4a), 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile (8a), indole-3-carbonitrile (9a) and indole-3-ylacetonitrile (10a) the acids were formed.
引用
收藏
页码:93 / 95
页数:3
相关论文
共 38 条
[1]   MICROBIAL DEGREDATION OF NITRILE COMPOUNDS .5. ALIPHATIC NITRILE HYDRATASE FROM ARTHROBACTER SP J-1 PURIFICATION AND CHARACTERIZATION [J].
ASANO, Y ;
FUJISHIRO, K ;
TANI, Y ;
YAMADA, H .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1982, 46 (05) :1165-1174
[2]  
BENNETT MA, 1973, J AM CHEM SOC, V95, P3030, DOI 10.1021/ja00790a057
[3]  
BOULTON AJ, 1984, COMPREHENSIVE HETERO, V2, P52
[4]  
BROWN DJ, 1984, COMPREHENSIVE HET 2B, V3, P81
[5]  
CHADWICK DJ, 1984, COMPREHENSIVE HETE 3, V4, P286
[6]   CATALYTIC HYDRATION OF ACRYLONITRILE TO ACRYLAMIDE UNDER MILD CONDITIONS [J].
CHIN, J ;
KIM, JH .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1990, 29 (05) :523-525
[7]   SELECTIVE HYDROLYSIS OF NITRILES UNDER MILD CONDITIONS BY AN ENZYME [J].
COHEN, MA ;
SAWDEN, J ;
TURNER, NJ .
TETRAHEDRON LETTERS, 1990, 31 (49) :7223-7226
[8]  
COOK MJ, 1966, J CHEM SOC CHEM COMM, P121
[9]  
CROUT DHG, 1989, MOD SYN MET, V5, P1
[10]  
DAVIES HG, 1989, BIOTRANSFORMATIONS P