ENZYMATIC-HYDROLYSIS OF HETEROCYCLIC NITRILES

被引：19

作者：

KLEMPIER, N

DERAADT, A

GRIENGL, H

HEINISCH, G

机构：

[1] GRAZ TECH UNIV, INST ORGAN CHEM, A-8010 GRAZ, AUSTRIA

[2] UNIV INNSBRUCK, INST ORGAN & PHARMACEUT CHEM, A-6020 INNSBRUCK, AUSTRIA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 01期

关键词：

D O I：

10.1002/jhet.5570290115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp. Pyrimidine-2-carbonitrile (2a) and 3-chloropyridazine-4-carbonitrile (4a) were converted into the corresponding amides while from 2-ethoxycarbonyl-4-pyridinecarbonitrile (1a), 6-methylpyridazine-3-carbonitrile (3a), 3-chloropyridazine-4-carbonitrile (4a), 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile (8a), indole-3-carbonitrile (9a) and indole-3-ylacetonitrile (10a) the acids were formed.

引用

页码：93 / 95

页数：3

共 38 条

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