THE USE OF MONOCLONAL-ANTIBODIES TO ACHIEVE IMMUNOLOGICAL-TOLERANCE

被引：12

作者：

WALDMANN, H

COBBOLD, S

机构：

[1] Department of Pathology, Cambridge, CB2 1QP, Tennis Court Road

[2] Department of Pathology, Cambridge, CB2 1QP, Tennis Court Road

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0165-6147(93)90198-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming, reviewed by Herman Waldmann and Stephen Cobbold, is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.

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收藏

页码：143 / 148

页数：6

相关论文

共 29 条

[1] MULTIPLE LEVELS OF PERIPHERAL TOLERANCE [J].

ARNOLD, B ;

SCHONRICH, G ;

HAMMERLING, GJ .

IMMUNOLOGY TODAY, 1993, 14 (01) :12-14

[2] INDUCTION OF TOLERANCE BY MONOCLONAL-ANTIBODY THERAPY [J].

BENJAMIN, RJ ;

WALDMANN, H .

NATURE, 1986, 320 (6061) :449-451

[3] MECHANISMS OF MONOCLONAL ANTIBODY-FACILITATED TOLERANCE INDUCTION - A POSSIBLE ROLE FOR THE CD4 (L3T4) AND CD11A (LFA-1) MOLECULES IN SELF-NON-SELF DISCRIMINATION [J].

BENJAMIN, RJ ;

QIN, SX ;

WISE, MP ;

COBBOLD, SP ;

WALDMANN, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (07) :1079-1088

[4]

BREWER Y, 1989, LANCET, V2, P935

[5] INFLUENCE OF LANGERHANS CELLS ON THE SURVIVAL OF H-Y INCOMPATIBLE SKIN-GRAFTS IN RATS [J].

CHEN, HD ;

SILVERS, WK .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 81 (01) :20-23

[6] TOLERANCE IN THE MOUSE TO MAJOR HISTOCOMPATIBILITY COMPLEX-MISMATCHED HEART ALLOGRAFTS, AND TO RAT-HEART XENOGRAFTS, USING MONOCLONAL-ANTIBODIES TO CD4 AND CD8 [J].

CHEN, ZH ;

COBBOLD, S ;

METCALFE, S ;

WALDMANN, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (03) :805-810

[7] REPROGRAMMING THE IMMUNE-SYSTEM FOR PERIPHERAL TOLERANCE WITH CD4 AND CD8 MONOCLONAL-ANTIBODIES [J].

COBBOLD, SP ;

QIN, SX ;

LEONG, LYW ;

MARTIN, G ;

WALDMANN, H .

IMMUNOLOGICAL REVIEWS, 1992, 129 :165-201

[8] THE INDUCTION OF SKIN-GRAFT TOLERANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX-MISMATCHED OR PRIMED RECIPIENTS - PRIMED T-CELLS CAN BE TOLERIZED IN THE PERIPHERY WITH ANTI-CD4 AND ANTI-CD8 ANTIBODIES [J].

COBBOLD, SP ;

MARTIN, G ;

WALDMANN, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (12) :2747-2755

[9] EVIDENCE THAT THE T-CELL REPERTOIRE OF NORMAL RATS CONTAINS CELLS WITH THE POTENTIAL TO CAUSE DIABETES - CHARACTERIZATION OF THE CD4+ T-CELL SUBSET THAT INHIBITS THIS AUTOIMMUNE POTENTIAL [J].

FOWELL, D ;

MASON, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (03) :627-636

[10]

GASPARI AA, 1988, J IMMUNOL, V140, P2956