MULTIPLE LEVELS OF PERIPHERAL TOLERANCE

被引：187

作者：

ARNOLD, B

SCHONRICH, G

HAMMERLING, GJ

机构：

[1] Bernd Arnold, Günther Schönrich and Günter J. Hämmerling are at the Division of Somatic Genetics, Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 01期

关键词：

D O I：

10.1016/0167-5699(93)90317-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The establishment and maintenance of self tolerance is based on multiple events in the thymus and periphery, resulting in either deletion of self-reactive T cells or induction of nonresponsiveness. Here, Bernd Arnold and colleagues propose that, depending on the tolerogenic signals, peripheral T cells can reach different levels of tolerance with regard to their capacity for reactivation. In addition, it appears that tolerant T cells are still susceptible to further tolerogenic signals, driving them into a deeper state of tolerance. Thus, induction of T-cell tolerance can be viewed as a multistep mechanism.

引用

页码：12 / 14

页数：3

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