SEPARATION OF SOME ENANTIOMERS AND DIASTEREOMERS OF PROPRANOLOL DERIVATIVES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：23

作者：

FACKLAM, C

MODLER, A

机构：

[1] Max-Planck-Gesellschaft, Arbeitsgruppe Asymmetrische Katalyse an der Universitat Rostock (in the Inst. fur Organische Katalys, 18055 Rostock

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 664卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)87009-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The separation of some propranolol analogues I into their enantiomers and diastereomers respectively, by HPLC succeeded with cellulose tris(3,5-dimethylphenylcarbamate) as a chiral stationary phase and hexane-alcohol and aqueous NaClO4-acetonitrile as mobile phases. Retention times and alpha values depend on the substituents R(1) and R(2). With non-aromatic substituents R(1) or R(2) the R-enantiomers are eluted first whereas with aromatic substituents the S-enantiomers, surprisingly, have shorter retention times. [GRAPHICS] ]

引用

页码：203 / 211

页数：9

共 13 条

[1] CHROMATOGRAPHIC RESOLUTION OF THE CHIRAL ISOMERS OF SEVERAL BETA-BLOCKERS OVER CELLULOSE TRIS(3,5-DIMETHYLPHENYLCARBAMATE) CHIRAL STATIONARY PHASE
CHING, CB
LIM, BG
LEE, EJD
NG, SC
[J]. CHIRALITY, 1992, 4 (03) : 174 - 177
[2] RETENTION, ENANTIOSELECTIVITY AND ENANTIOMERIC ELUTION ORDER OF PROPRANOLOL AND ITS ESTER DERIVATIVES ON AN ALPHA1-ACID GLYCOPROTEIN-BONDED COLUMN
HAGINAKA, J
SEYAMA, C
YASUDA, H
TAKAHASHI, K
[J]. CHROMATOGRAPHIA, 1992, 33 (3-4) : 127 - 132
[3] CELLULOSIC CHIRAL STATIONARY PHASE UNDER REVERSED-PHASE CONDITION
ISHIKAWA, A
SHIBATA, T
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1993, 16 (04): : 859 - 878
[4] JIRA T, 1991, PHARMAZIE, V46, P432
[5] KRAUSE HW, 1992, PHARMAZIE, V47, P838
[6] LIQUID AND HIGH-PRESSURE CARBON-DIOXIDE CHROMATOGRAPHY OF BETA-BLOCKERS - RESOLUTION OF THE ENANTIOMERS OF NADOLOL
LEE, CR
PORZIEMSKY, JP
AUBERT, MC
KRSTULOVIC, AM
[J]. JOURNAL OF CHROMATOGRAPHY, 1991, 539 (01): : 55 - 69
[7] CHROMATOGRAPHIC RESOLUTION .12. OPTICAL RESOLUTION OF BETA-BLOCKERS BY HPLC ON CELLULOSE TRIPHENYLCARBAMATE DERIVATIVES
OKAMOTO, Y
KAWASHIMA, M
ABURATANI, R
HATADA, K
NISHIYAMA, T
MASUDA, M
[J]. CHEMISTRY LETTERS, 1986, (07) : 1237 - 1240
[8] CHIRAL SEPARATIONS OF BETA-BLOCKING DRUG SUBSTANCES USING DERIVATIZATION WITH CHIRAL REAGENTS AND NORMAL-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
OLSEN, L
BRONNUMHANSEN, K
HELBOE, P
JORGENSEN, GH
KRYGER, S
[J]. JOURNAL OF CHROMATOGRAPHY, 1993, 636 (02): : 231 - 241
[9] DIRECT ENANTIOMERIC SEPARATION OF BETA-BLOCKERS ON CHYROSINE-A BY SUPERCRITICAL FLUID CHROMATOGRAPHY - SUPERCRITICAL CARBON-DIOXIDE AS TRANSIENT INSITU DERIVATIZING AGENT
SIRET, L
BARGMANN, N
TAMBUTE, A
CAUDE, M
[J]. CHIRALITY, 1992, 4 (04) : 252 - 262
[10] IMPROVEMENT OF THE ENANTIORECOGNITION ABILITY OF TYROSINE-DERIVED CHIRAL STATIONARY PHASES - DIRECT RESOLUTION OF 1,2-AMINO-ALCOHOLS (BETA-BLOCKERS)
TAMBUTE, A
SIRET, L
BEGOS, A
CAUDE, M
[J]. CHIRALITY, 1992, 4 (01) : 36 - 42

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