CLONING, FUNCTIONAL EXPRESSION AND MESSENGER-RNA DISTRIBUTION OF AN INWARDLY RECTIFYING POTASSIUM CHANNEL PROTEIN

被引：35

作者：

FALK, T

MEYERHOF, W

CORRETTE, BJ

SCHAFER, J

BAUER, CK

SCHWARZ, JR

RICHTER, D

机构：

[1] UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST ZELLBIOCHEM & KLIN NEUROBIOL,D-20246 HAMBURG,GERMANY

[2] UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST PHYSIOL,D-20246 HAMBURG,GERMANY

[3] UNIV POTSDAM,DEUTSCH INST ERNAHRUNGSFORSCH,MOLEK GENET ABT,D-14558 POTSDAM,GERMANY

来源：

FEBS LETTERS | 1995年 / 367卷 / 02期

关键词：

GH3/B6; CELLS; HYBRIDIZATION; IN SITU; OOCYTE EXPRESSION; HUMAN EMBRYONIC KIDNEY CELL EXPRESSION; ANTERIOR PITUITARY; PROLACTIN SECRETION;

D O I：

10.1016/0014-5793(95)00527-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In GH(3)/B-6 cells at least two different inward K+ currents are observed that are regulated by thyrotropin-releasing hormone and somatostatin, respectively, Using a polymerase chain reaction based approach a cDNA was isolated and functionally expressed in human embryonic kidney cells that encodes an inward rectifier K+ channel, rIRK3, with a predicted molecular mass of 49.7 kDa, Corresponding transcripts of 2.6 kb have been detected in rat brain, pituitary and GH(3)/B-6 cells, In situ hybridization revealed that rIRK3 mRNA is distributed throughout the brain and occurs predominantly in the piriform cortex, indusium griseum, supraoptic nucleus, facial nucleus and cerebellar Purkinje cells.

引用

页码：127 / 131

页数：5

共 23 条

[1] RETRACTED: CLONING AND FUNCTIONAL EXPRESSION OF A RAT-HEART K-ATP CHANNEL (RETRACTED ARTICLE. SEE VOL 378, PG 792, 1995) [J].