AND LOCALIZATION OF A G-PROTEIN-COUPLED INWARDLY RECTIFYING K+ CHANNEL IN THE RAT

被引:83
作者
KARSCHIN, C
SCHREIBMAYER, W
DASCAL, N
LESTER, H
DAVIDSON, N
KARSCHIN, A
机构
[1] MAX PLANCK INST BIOPHYS CHEM,D-37077 GOTTINGEN,GERMANY
[2] CALTECH,DIV BIOL,PASADENA,CA 91125
[3] GRAZ UNIV,INST MED PHYS & BIOPHYS,A-8010 GRAZ,AUSTRIA
[4] TEL AVIV UNIV,DEPT PHYSIOL & PHARMACOL,IL-69978 RAMAT AVIV,ISRAEL
关键词
POTASSIUM CHANNEL; INWARD RECTIFIER; G-PROTEIN GATING; MESSENGER-RNA; HYBRIDIZATION (IN SITU);
D O I
10.1016/0014-5793(94)00590-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cellular distribution of the mRNA of the inwardly rectifying K+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein-activated K+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II-VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons supports its important role as a major target channel for G protein mediated receptor function.
引用
收藏
页码:139 / 144
页数:6
相关论文
共 22 条
[1]   A-G PROTEIN COUPLES SEROTONIN AND GABA-B RECEPTORS TO THE SAME CHANNELS IN HIPPOCAMPUS [J].
ANDRADE, R ;
MALENKA, RC ;
NICOLL, RA .
SCIENCE, 1986, 234 (4781) :1261-1265
[2]   UNCOUPLING OF CARDIAC MUSCARINIC AND BETA-ADRENERGIC RECEPTORS FROM ION CHANNELS BY A GUANINE-NUCLEOTIDE ANALOG [J].
BREITWIESER, GE ;
SZABO, G .
NATURE, 1985, 317 (6037) :538-540
[3]   MEMBRANE-DELIMITED CELL SIGNALING COMPLEXES - DIRECT ION CHANNEL REGULATION BY G-PROTEINS [J].
BROWN, AM .
JOURNAL OF MEMBRANE BIOLOGY, 1993, 131 (02) :93-104
[4]  
BROWN DA, 1990, ANNU REV PHYSIOL, V52, P215
[5]   THE ALPHA SUBUNIT OF THE GTP BINDING PROTEIN-GK OPENS ATRIAL POTASSIUM CHANNELS [J].
CODINA, J ;
YATANI, A ;
GRENET, D ;
BROWN, AM ;
BIRNBAUMER, L .
SCIENCE, 1987, 236 (4800) :442-445
[6]   ATRIAL G-PROTEIN-ACTIVATED K+-CHANNEL - EXPRESSION CLONING AND MOLECULAR-PROPERTIES [J].
DASCAL, N ;
SCHREIBMAYER, W ;
LIM, NF ;
WANG, WZ ;
CHAVKIN, C ;
DIMAGNO, L ;
LABARCA, C ;
KIEFFER, BL ;
GAVERIAUXRUFF, C ;
TROLLINGER, D ;
LESTER, HA ;
DAVIDSON, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10235-10239
[7]   G-PROTEIN-COUPLED MECHANISMS AND NERVOUS SIGNALING [J].
HILLE, B .
NEURON, 1992, 9 (02) :187-195
[8]   CLONING AND EXPRESSION OF AN INWARDLY RECTIFYING ATP-REGULATED POTASSIUM CHANNEL [J].
HO, K ;
NICHOLS, CG ;
LEDERER, WJ ;
LYTTON, J ;
VASSILEV, PM ;
KANAZIRSKA, MV ;
HEBERT, SC .
NATURE, 1993, 362 (6415) :31-38
[9]   PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A MOUSE INWARD RECTIFIER POTASSIUM CHANNEL [J].
KUBO, Y ;
BALDWIN, TJ ;
JAN, YN ;
JAN, LY .
NATURE, 1993, 362 (6416) :127-133
[10]   PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A RAT G-PROTEIN-COUPLED MUSCARINIC POTASSIUM CHANNEL [J].
KUBO, Y ;
REUVENY, E ;
SLESINGER, PA ;
JAN, YN ;
JAN, LY .
NATURE, 1993, 364 (6440) :802-806