CONTRASTING EFFECTS OF CLONIDINE AND DIAZEPAM ON TESTS OF WORKING-MEMORY AND PLANNING

被引:110
作者
COULL, JT
MIDDLETON, HC
ROBBINS, TW
SAHAKIAN, BJ
机构
[1] UNIV CAMBRIDGE,DEPT EXPTL PSYCHOL,CAMBRIDGE CB2 3EB,ENGLAND
[2] UNIV CAMBRIDGE,ADDENBROOKES HOSP,SCH CLIN,DEPT PSYCHIAT,CAMBRIDGE CB2 2QQ,ENGLAND
基金
英国惠康基金;
关键词
ALPHA(2) ADRENOCEPTOR; BENZODIAZEPINE; FRONTAL CORTEX; EXECUTIVE FUNCTION;
D O I
10.1007/BF02311179
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The alpha(2) adrenoceptor has recently been implicated in working memory (WM), a function dependent on the integrity of the prefrontal cortex. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 mu g/kg and 2.5 mu g/kg) of the mixed alpha(1)/alpha(2) adrenoceptor agonist clonidine (CLO) on performance of various computerised tests of WM and planning in healthy, young volunteers. These are compared to the effects produced by two doses (5 mg and 10 mg) of diazepam (DZP) on largely the same set of neuropsychological tests in a comparable set of subjects. Administration of CLO resulted in impulsivity of responding in a planning task, as well as differential dose-dependent effects on two analogous tests of spatial and visual WM. The nature of these effects were suggestive of mnemonic, rather than executive, dysfunction. Conversely, DZP produced specific deficits on tests of spatial WM and planning very similar to those seen following lesions to the frontal lobes. Therefore, these two sedative drugs produce doubly dissociable, dose-dependent effects on different aspects of cognitive function.
引用
收藏
页码:311 / 321
页数:11
相关论文
共 41 条
[1]   CENTRAL NEURONAL PATHWAYS AND THE PROCESS OF ANESTHESIA [J].
ANGEL, A .
BRITISH JOURNAL OF ANAESTHESIA, 1993, 71 (01) :148-163
[2]  
ARNSTEN AFT, 1988, J NEUROSCI, V8, P4287
[3]   ALPHA-2 ADRENERGIC AGONISTS DECREASE DISTRACTIBILITY IN AGED MONKEYS PERFORMING THE DELAYED-RESPONSE TASK [J].
ARNSTEN, AFT ;
CONTANT, TA .
PSYCHOPHARMACOLOGY, 1992, 108 (1-2) :159-169
[4]   ALPHA-2-ADRENERGIC MECHANISMS IN PREFRONTAL CORTEX ASSOCIATED WITH COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES [J].
ARNSTEN, AFT ;
GOLDMANRAKIC, PS .
SCIENCE, 1985, 230 (4731) :1273-1276
[5]  
Baddeley A. D., 1986, WORKING MEMORY
[6]   COGNITIVE DEFICIT CAUSED BY REGIONAL DEPLETION OF DOPAMINE IN PREFRONTAL CORTEX OF RHESUS-MONKEY [J].
BROZOSKI, TJ ;
BROWN, RM ;
ROSVOLD, HE ;
GOLDMAN, PS .
SCIENCE, 1979, 205 (4409) :929-932
[7]  
CHARNEY DS, 1986, ARCH GEN PSYCHIAT, V43, P1042
[8]   CATECHOLAMINES AND THE COVERT ORIENTATION OF ATTENTION IN HUMANS [J].
CLARK, CR ;
GEFFEN, GM ;
GEFFEN, LB .
NEUROPSYCHOLOGIA, 1989, 27 (02) :131-139
[9]  
Cochran WG, 1957, EXPT DESIGNS, P127
[10]  
COULL JT, 1995, IN PRESS PSYCHOPHARM