INVITRO ACTIVITY OF DAPTOMYCIN-METRONIDAZOLE COMBINATIONS AGAINST MIXED BACTERIAL CULTURES - REDUCED ACTIVITY OF METRONIDAZOLE AGAINST BACTEROIDES SPECIES IN THE PRESENCE OF ENTEROCOCCUS-FAECALIS

被引：14

作者：

NAGY, E ^{[1
]}

WERNER, H ^{[1
]}

HEIZMANN, W ^{[1
]}

机构：

[1] UNIV TUBINGEN,DEPT MED MICROBIOL,W-7400 TUBINGEN 1,GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1990年 / 9卷 / 04期

关键词：

D O I：

10.1007/BF01968064

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in vitro activity of daptomycin-metronidazole combinations against mixed cultures of gram-positive facultative cocci and strains of the Bacteroides fragilis group was investigated. Metronidazole did not influence the high activity of daptomycin against strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis in the absence or presence of the co-cultured Bacteroides strains. In contrast, the Enterococcus faecalis isolates protected the co-cultured Bacteroides strains against the killing effect of metronidazole, even at a concentration four- or eightfold the MIC of metronidazole. Killing curve experiments confirmed this protective effect of different isolates of Enterococcus faecalis. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

引用

页码：287 / 291

页数：5

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