SYNTHESIS OF A GALACTOSE-FUCOSE DISACCHARIDE MIMIC OF SIALYL-LEWIS-X

被引：29

作者：

RAGAN, JA

COOPER, K

机构：

[1] Pfizer Central Research, Groton, CT 06340, Eastern Point Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80284-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Disaccharide 4 was designed as a structurally simplified, potential mimic of sialyl Lewis X (1). 4 was prepared utilizing Schmidt's trichloroacetimidate methodology in 10 linear steps from methyl galactoside 5. 4 exhibited activity in an E-selectin binding assay at concentrations 40 to 45-fold higher than that observed for monomeric sialyl Lewis X.

引用

页码：2563 / 2566

页数：4

共 26 条

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