THE ABSOLUTE-CONFIGURATION OF (+)-ALPHA-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE, AND ITS PERMEATION THROUGH THE SEAL BLOOD-BRAIN-BARRIER

被引：30

作者：

MOLLER, K

BRETZKE, C

HUHNERFUSS, H

KALLENBORN, R

KINKEL, JN

KOPF, J

RIMKUS, G

机构：

[1] UNIV HAMBURG,INST ORGAN CHEM,D-20146 HAMBURG,GERMANY

[2] UNIV HAMBURG,INST ANORGAN & ANGEW CHEM,W-2000 HAMBURG,GERMANY

[3] E MERCK AG,FO REAG CHROM ABT,W-6100 DARMSTADT,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 08期

关键词：

D O I：

10.1002/anie.199408821

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Not the result of enzymatic degradation processes, but of the “preferential permeability” of the blood–brain barrier for (+)‐α‐hexachlorocyclohexane (HCH)—this is the interpretation of the selective accumulation of this enantiomer in seal brain. This conclusion could be drawn only after the α‐HCH isomers were successfully separated on a chiral phase by HPLC. The structure of the (+) enantiomer was determined by X‐ray crystallography, but the structural elements responsible for the selective transfer are still unknown. Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：882 / 884

页数：3

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