HOW DOES THE 3'-PHOSPHATE DRIVE THE SUGAR CONFORMATION IN DNA

被引：42

作者：

PLAVEC, J ^{[1
]}

THIBAUDEAU, C ^{[1
]}

VISWANADHAM, G ^{[1
]}

SUND, C ^{[1
]}

CHATTOPADHYAYA, J ^{[1
]}

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT BIOORGAN CHEM,BOX 581,S-75123 UPPSALA,SWEDEN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 06期

关键词：

D O I：

10.1039/c39940000781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

While the 3J(C(4')P), 3J(C(2')P), 3J(H(3')P), 3J(CH3P) and 3J(CH2P) coupling constants in simple model systems 13-16 remain unchanged over 278-358 K, considerable changes of endocyclic 3J(HH) coupling constants have been found to take place, which, for the first time, unequivocally show that the change of the North (3'-endo-2'-exo) reversible South (3'-exo-2'-endo) sugar pseudorotamer equilibrium is independent of the change of the phosphate backbone torsion, it is also found that the gauche effects between O(4') and 3'-OPO3H- in 9-12 and between O(4') and 3'-OPO3Et- in 13-16 are responsible for the stabilization of the South sugar conformer by DELTAH-degrees = - 1.5 kJ mol-1 compared to 3'-OH in 5-8.

引用

页码：781 / 783

页数：3

共 28 条

[1] THE SELF-CLEAVAGE OF LARIAT-RNA [J].

AGBACK, P ;

GLEMAREC, C ;

YIN, L ;

SANDSTROM, A ;

PLAVEC, J ;

SUND, C ;

YAMAKAGE, S ;

VISWANADHAM, G ;

ROUSSE, B ;

PURI, N ;

CHATTOPADHYAYA, J .

TETRAHEDRON LETTERS, 1993, 34 (24) :3929-3932

[2] SOLUTION STRUCTURE OF LARIAT RNA BY 500 MHZ NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS STUDIES IN WATER [J].

AGBACK, P ;

SANDSTROM, A ;

YAMAKAGE, S ;

SUND, C ;

GLEMAREC, C ;

CHATTOPADHYAYA, J .

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1993, 27 (03) :229-259

[3] RELATIONSHIP BETWEEN PROTON PROTON NMR COUPLING-CONSTANTS AND SUBSTITUENT ELECTRONEGATIVITIES .5. EMPIRICAL SUBSTITUENT CONSTANTS DEDUCED FROM ETHANES AND PROPANES [J].

ALTONA, C ;

IPPEL, JH ;

HOEKZEMA, AJAW ;

ERKELENS, C ;

GROESBEEK, M ;

DONDERS, LA .

MAGNETIC RESONANCE IN CHEMISTRY, 1989, 27 (06) :564-576

[4] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - NEW DESCRIPTION USING CONCEPT OF PSEUDOROTATION [J].

ALTONA, C ;

SUNDARALINGAM, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (23) :8205-+

[5] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - IMPROVED METHOD FOR INTERPRETATION OF PROTON MAGNETIC-RESONANCE COUPLING-CONSTANTS [J].

ALTONA, C ;

SUNDARALINGAM, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (07) :2333-2344

[6]

ALTONA C, 1982, RECL TRAV CHIM PAY B, V101, P413

[7] CONFORMATIONAL STUDY OF RIBONUCLEOTIDES, 2'-DEOXYRIBONUCLEOTIDES, AND ARABINONUCLEOTIDES BY C-13 NUCLEAR MAGNETIC-RESONANCE [J].

BLONSKI, WJP ;

HRUSKA, FE ;

SADANA, KL ;

LOEWEN, PC .

BIOPOLYMERS, 1983, 22 (02) :605-616

[8] INTIMATE DETAILS OF CONFORMATIONAL CHARACTERISTICS OF DEOXYRIBODINUCLEOSIDE MONOPHOSPHATES IN AQUEOUS-SOLUTION [J].

CHENG, DM ;

SARMA, RH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (22) :7333-7348

[9] Z-RNA - THE SOLUTION NMR STRUCTURE OF R(CGCGCG) [J].

DAVIS, PW ;

ADAMIAK, RW ;

TINOCO, I .

BIOPOLYMERS, 1990, 29 (01) :109-122

[10] THE TETRARIBONUCLEOTIDE RCPGPCPG FORMS A LEFT-HANDED Z-RNA DOUBLE-HELIX [J].

DAVIS, PW ;

HALL, K ;

CRUZ, P ;

TINOCO, I ;

NEILSON, T .

NUCLEIC ACIDS RESEARCH, 1986, 14 (03) :1279-1291

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