THE EFFECT OF AGE, SEX, WEIGHT AND HEIGHT ON THE PLASMA-CONCENTRATIONS IN HEALTHY-SUBJECTS OF THE ACIDIC METABOLITES OF SOME BIOGENIC MONOAMINES INVOLVED IN PSYCHIATRIC AND NEUROLOGICAL DISORDERS

被引:7
作者
DAVIS, BA [1 ]
DURDEN, DA [1 ]
OREILLY, RL [1 ]
机构
[1] ST THOMAS PSYCHIAT HOSP,ST THOMAS,ONTARIO,CANADA
关键词
AGE; CONJUGATED PHENYLACETIC ACID; HEIGHT; HOMOVANILLIC ACID; 5-HYDROXY-INDOLEACETIC ACID; INDOLEACETIC ACID; MANDELIC ACID; META-HYDROXYPHENYLACETIC ACID; PARA-HYDROXYMANDELIC ACID; PARA-HYDROXYPHENYLACETIC ACID; PLASMA; SEX; UNCONJUGATED PHENYLACETIC ACID; VANILLYLMANDELIC ACID; WEIGHT;
D O I
10.1016/0278-5846(91)90025-V
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. The plasma concentrations of unconjugated phenylacetic acid and m-hydroxy-phenylacetic acid are lower in male than in female subjects. 2. The plasma concentrations of unconjugated phenylacetic acid and mandelic acid decrease with increasing weight and height for all subjects combined- The same relationships apply for both males and females but are significant only for males. 3. Homovanillic and vanillylmandelic acid concentrations in plasma increase with age. 4. The importance of using age, sex, weight and height matched groups in studies involving the plasma concentrations of some of the trace amine metabolites in psychiatric disorders has been demonstrated. This is particularly the case for phenylacetic acid, the major metabolite of phenylethylamine which is now thought to be a neuromodulator of catecholaminergic neurotransmission.
引用
收藏
页码:503 / 512
页数:10
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