EARLY EXPOSURE TO COWS MILK AND SOLID FOODS IN INFANCY, GENETIC PREDISPOSITION, AND RISK OF IDDM

被引:150
作者
KOSTRABA, JN
CRUICKSHANKS, KJ
LAWLERHEAVNER, J
JOBIM, LF
REWERS, MJ
GAY, EC
CHASE, HP
KLINGENSMITH, G
HAMMAN, RF
机构
[1] UNIV COLORADO,DEPT PEDIAT,DENVER,CO 80202
[2] UNIV OXFORD,JOHN RADCLIFF HOSP,NUFFIELD DEPT SURG,OXFORD,ENGLAND
关键词
D O I
10.2337/diabetes.42.2.288
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Using a case-control study design, we examined the hypothesis that early exposure to cow's milk and solid foods increased the risk of IDDM. An infant diet history was collected from 164 IDDM subjects from the Colorado IDDM Registry with a mean birth year of 1973, and 145 nondiabetic population control subjects who were frequency matched to diabetic subjects on age, sex, and ethnicity. Early exposure was defined as exposure occurring before 3 mo of age. After controlling for ethnicity, birth order, and family income, more diabetic subjects were exposed early to cow's milk (OR 4.5, 95% Cl 0.9-21.4) and solid foods (OR 2.5, Cl 1.4-4.3) than control subjects. To examine this association while accounting for the genetic susceptibility to IDDM, we defined individuals as high and low risk by an HLA-DQB1 molecular marker. Early exposure to cow's milk was not associated with elevated risk for IDDM in low-risk individuals. Relative to unexposed low-risk individuals, early exposure to cow's milk was strongly associated in individuals with a high risk marker (OR 11.3, Cl 1.2-102.0). Similar findings were observed for early exposure to solid foods. These data indicate that early exposure to cow's milk and solid foods may be associated with increased risk of IDDM. The inclusion of HLA-encoded risk in the analyses demonstrates the combined effect of genetic and environmental factors.
引用
收藏
页码:288 / 295
页数:8
相关论文
共 42 条
  • [11] DIABETES IN WESTERN AUSTRALIAN CHILDREN - DESCRIPTIVE EPIDEMIOLOGY
    GLATTHAAR, C
    WHITTALL, DE
    WELBORN, TA
    GIBSON, MJ
    BROOKS, BH
    RYAN, MMP
    BYRNE, GC
    [J]. MEDICAL JOURNAL OF AUSTRALIA, 1988, 148 (03) : 117 - 123
  • [12] RELIABILITY OF RETROSPECTIVE SURVEY DATA ON INFANT-FEEDING
    HAAGA, JG
    [J]. DEMOGRAPHY, 1988, 25 (02) : 307 - 314
  • [13] ON THE RELIABILITY OF THE ANAMNESTIC INTERVIEW
    HAGGARD, EA
    BREKSTAD, A
    SKARD, AG
    [J]. JOURNAL OF ABNORMAL AND SOCIAL PSYCHOLOGY, 1960, 61 (03): : 311 - 318
  • [14] COLORADO-IDDM-REGISTRY - INCIDENCE AND VALIDATION OF IDDM IN CHILDREN AGED 0-17 YR
    HAMMAN, RF
    GAY, EC
    CRUICKSHANKS, KJ
    COOK, M
    LEZOTTE, DC
    KLINGENSMITH, GJ
    CHASE, HP
    [J]. DIABETES CARE, 1990, 13 (05) : 499 - 506
  • [15] HELGASON T, 1981, LANCET, V2, P716
  • [16] ALLELIC SEQUENCE VARIATION OF THE HLA-DQ LOCI - RELATIONSHIP TO SEROLOGY AND TO INSULIN-DEPENDENT DIABETES SUSCEPTIBILITY
    HORN, GT
    BUGAWAN, TL
    LONG, CM
    ERLICH, HA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) : 6012 - 6016
  • [17] DO MOTHERS OVERESTIMATE BREAST-FEEDING DURATION - AN EXAMPLE OF RECALL BIAS FROM A STUDY IN SOUTHERN BRAZIL
    HUTTLY, SRA
    BARROS, FC
    VICTORA, CG
    BERIA, JU
    VAUGHAN, JP
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (03) : 572 - 575
  • [18] COWS MILK PROTEIN-SENSITIVE ENTEROPATHY - IMPORTANT FACTOR IN PROLONGING DIARRHEA OF ACUTE INFECTIVE ENTERITIS IN EARLY INFANCY
    IYNGKARAN, N
    ROBINSON, MJ
    SUMITHRAN, E
    LAM, SK
    PUTHUCHEARY, SD
    YADAV, M
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1978, 53 (02) : 150 - 153
  • [19] A BOVINE ALBUMIN PEPTIDE AS A POSSIBLE TRIGGER OF INSULIN-DEPENDENT DIABETES-MELLITUS
    KARJALAINEN, J
    MARTIN, JM
    KNIP, M
    ILONEN, J
    ROBINSON, BH
    SAVILAHTI, E
    AKERBLOM, HK
    DOSCH, HM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (05) : 302 - 307
  • [20] VALIDITY OF MATERNAL REPORTING OF BREAST-FEEDING HISTORY AND THE ASSOCIATION WITH BLOOD-LIPIDS IN 17 YEAR OLDS IN JERUSALEM
    KARK, JD
    TROYA, G
    FRIEDLANDER, Y
    SLATER, PE
    STEIN, Y
    [J]. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 1984, 38 (03) : 218 - 225