HETEROGENEOUS DISTRIBUTION OF FUNCTIONALLY IMPORTANT AMINO-ACIDS IN BRAIN-AREAS OF ADULT AND AGING HUMANS

被引：41

作者：

BANAYSCHWARTZ, M ^{[1
]}

PALKOVITS, M ^{[1
]}

LAJTHA, A ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,SCH MED,NEUROMORPHOL LAB,H-1085 BUDAPEST 8,HUNGARY

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 04期

关键词：

REGIONAL AMINO ACIDS; AMINO ACIDS IN AGING; HUMAN BRAIN AMINO ACIDS;

D O I：

10.1007/BF00967245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regional distribution of seven amino acids thought to have inhibitory neurotransmitter or neurotransmitter precursor function-GABA, glycine, taurine, serine, threonine, phenylalanine, and tyrosine-was determined in 52 discrete areas from brain of adult and old humans. Significant heterogeneity was found, with 3- to 16-fold differences in levels in the various regions analyzed. The patterns of distribution were somewhat different from those in the adult or old rat brain. Relatively few changes were seen in old brain. Heterogeneity in distribution has to be taken into account in assessing physiological changes in amino acid levels and metabolism.

引用

页码：417 / 423

页数：7

共 38 条

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