HETEROGENEOUS DISTRIBUTION OF FUNCTIONALLY IMPORTANT AMINO-ACIDS IN BRAIN-AREAS OF ADULT AND AGING HUMANS

被引：41

作者：

BANAYSCHWARTZ, M ^{[1
]}

PALKOVITS, M ^{[1
]}

LAJTHA, A ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,SCH MED,NEUROMORPHOL LAB,H-1085 BUDAPEST 8,HUNGARY

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 04期

关键词：

REGIONAL AMINO ACIDS; AMINO ACIDS IN AGING; HUMAN BRAIN AMINO ACIDS;

D O I：

10.1007/BF00967245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regional distribution of seven amino acids thought to have inhibitory neurotransmitter or neurotransmitter precursor function-GABA, glycine, taurine, serine, threonine, phenylalanine, and tyrosine-was determined in 52 discrete areas from brain of adult and old humans. Significant heterogeneity was found, with 3- to 16-fold differences in levels in the various regions analyzed. The patterns of distribution were somewhat different from those in the adult or old rat brain. Relatively few changes were seen in old brain. Heterogeneity in distribution has to be taken into account in assessing physiological changes in amino acid levels and metabolism.

引用

页码：417 / 423

页数：7

共 38 条

[11] BRAIN AMINO-ACIDS IN BABOONS WITH LIGHT-INDUCED EPILEPSY
HANSEN, S
PERRY, TL
WADA, JA
SOKOL, M
[J]. BRAIN RESEARCH, 1973, 50 (02) : 480 - 483
[12] HATEGAN D, 1990, Revue Roumaine de Neurologie et Psychiatrie, V28, P15
[13] CHANGES IN FREE AMINO-ACID-CONCENTRATIONS IN SERUM, BRAIN, AND CSF THROUGHOUT EMBRYOGENESIS
HUETHER, G
LAJTHA, A
[J]. NEUROCHEMICAL RESEARCH, 1991, 16 (02) : 145 - 150
[14] AGE-DEPENDENT CHANGES IN BRAIN GLYCINE CONCENTRATION AND STRYCHNINE-INDUCED SEIZURES IN THE RAT
HUNTER, C
CHUNG, E
VANWOERT, MH
[J]. BRAIN RESEARCH, 1989, 482 (02) : 247 - 251
[15] JENSEN KL, 1991, BRAIN RES, V566, P225
[16] CONTROL OF CEREBRAL METABOLITE LEVELS .2. AMINO ACID UPTAKE AND LEVELS IN VARIOUS AREAS OF RAT BRAIN
KANDERA, J
LEVI, G
LAJTHA, A
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 126 (01) : 249 - &
[17] KLUNK WE, 1991, BIOL PSYCHIAT, V29, pA122
[18] PERINATAL CHANGES IN FREE AMINO-ACID POOL OF BRAIN IN MICE
LAJTHA, A
TOTH, J
[J]. BRAIN RESEARCH, 1973, 55 (01) : 238 - 241
[19] POSTMORTEM CHANGES IN CEREBRAL FREE AMINO-ACID POOL
LAJTHA, A
TOTH, J
[J]. BRAIN RESEARCH, 1974, 76 (03) : 546 - 551
[20] ABNORMALITIES IN THE LEVELS OF EXTRACELLULAR AND TISSUE AMINO-ACIDS IN THE BRAIN OF THE SEIZURE-SUSCEPTIBLE RAT
LEHMANN, A
[J]. EPILEPSY RESEARCH, 1989, 3 (02) : 130 - 137

← 1 2 3 4 →