CLONING OF THE HUMAN TAURINE TRANSPORTER AND CHARACTERIZATION OF TAURINE UPTAKE IN THYROID-CELLS

被引：116

作者：

JHIANG, SM

FITHIAN, L

SMANIK, P

MCGILL, J

TONG, Q

MAZZAFERRI, EL

机构：

[1] Department of Internal Medicine, The Ohio State University, Columbus

来源：

FEBS LETTERS | 1993年 / 318卷 / 02期

关键词：

HUMAN; THYROID; TAURINE; TRANSPORTER; CDNA; SEQUENCE;

D O I：

10.1016/0014-5793(93)80008-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone encoding a taurine transporter, designated HTAU, has been isolated from human thyroid. It contains an open reading frame encoding a protein of 619 amino acids with a calculated molecular weight of 69,675 Da. The predicted amino acid sequence of HTAU is highly homologous to those of dog kidney and rat brain. The HTAU mRNA was detectable in various human tissues examined. Transient expression of HTAU in COS-7 cells conferred a higher taurine uptake. The taurine uptake in FRTL-5 cells appears to be regulated by thyrotropin through cAMP. Finally, a higher taurine uptake may be associated with a higher proliferation rate in some cultured cell lines.

引用

页码：139 / 144

页数：6

共 18 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].