INFLUENCE OF METYRAPONE AND PHENOBARBITAL ON SODIUM DICHROMATE NEPHROTOXICITY IN DEVELOPING RATS

被引：12

作者：

APPENROTH, D

GAMBARYAN, S

FRIESE, KH

BRAUNLICH, H

机构：

[1] ACAD SCI USSR,INST EVOLUT PHYSIOL & BIOCHEM,LENINGRAD,USSR

[2] CHEM IND GDR,CTR HYG,LEUNA,GERMANY

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1990年 / 10卷 / 03期

关键词：

age dependence; metyrapone; nephrotoxicity; phenobarbital; sodium dichromate;

D O I：

10.1002/jat.2550100314

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

After the administration of equal doses of sodium dichromate, chromium concentrations in the kidney were lower in young than in adult rats. To test the age‐dependent sensitivity to the nephrotoxicity of dichromate, young and adult rats were given doses to achieve identical chromium conceätrations in the kidney. At equal renal concentrations, young rats had less functional and morphological damage than adult rats. As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age‐dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：227 / 232

页数：6

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