LIVE ATTENUATED SALMONELLA VACCINES AND THEIR POTENTIAL AS ORAL COMBINED VACCINES CARRYING HETEROLOGOUS ANTIGENS

被引：25

作者：

HORMAECHE, CE

机构：

[1] Division of Microbiology and Parasitology, Department of Pathology, Cambridge

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1991年 / 142卷 / 01期

关键词：

MICROBIOLOGY; SALMONELLA; VACCINE; IMMUNITY;

D O I：

10.1016/0022-1759(91)90298-T

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Live attenuated salmonellae are protective, and are candidate vaccines against invasive salmonella infections in man and animals. Different attenuating mutations have been described, and more than one can be incorporated in a vaccine for added safety. Combined salmonella vaccines express target carbohydrate and protein antigens or epitopes from viruses, bacteria and eukaryotic parasites, either within or on the surface of the cell, as capsules, fimbriae, or in the flagellin. Humoral, secretory and cellular responses to the recombinant antigens has been demonstrated. Experimental protection against diseases including streptococcal infection, tetanus, influenza and malaria has been obtained.

引用

页码：113 / 120

页数：8

共 92 条

[81] ORAL IMMUNIZATION OF MICE WITH ATTENUATED SALMONELLA-TYPHIMURIUM CONTAINING A RECOMBINANT PLASMID WHICH CODES FOR PRODUCTION OF A 31-KILODALTON PROTEIN OF BRUCELLA-ABORTUS [J].